Impact of other macronutrient composition within high-protein diet on body composition and cardiometabolic health: a systematic review, pairwise, and network meta-analysis of randomized controlled trials
Authors' conclusion
HPDs effectively reduce FM and increase LBM, and offers potential cardiometabolic benefits. Additionally, the manipulation of carbohydrate content in HPDs may further influence these outcomes.
Study context
- Population
- RCTs of High-protein Diets (HPDs); search of PubMed, Embase, CINAHL and Web of Science83 articles
- Comparison
- High-protein diets vs normal-protein diets
- Outcome
- Body composition
Pooled result
As reported in the abstract
HPDs vs Normal-protein dietsSMD (95% CI)
Body mass
−0.25(−0.40 to −0.11)
BMI
−0.26(−0.38 to −0.15)
Waist circumference
−0.19(−0.33 to −0.04)
HPDs vs Normal-protein dietsMD, kg (95% CI)
Fat mass
−0.64(−0.98 to −0.29)
Lean body mass
0.34(0.11–0.57)
Further pooled results
Network meta-analysis ranking by macronutrient composition
- High-protein, moderate-carbohydrate, high-fat diet ranked best for reducing body mass (BM), body mass index (BMI), waist circumference (WC), fat mass (FM), systolic and diastolic blood pressure and increasing lean body mass (LBM)
- High-protein, low-carbohydrate, high-fat diet scored highest for reducing TG and increasing HDL-C
Original publication
Impact of other macronutrient composition within high-protein diet on body composition and cardiometabolic health: a systematic review, pairwise, and network meta-analysis of randomized controlled trials. Int J Obes (Lond). Published 14 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →