Sex‐ and time‐specific associations of obesity with glycaemic traits: A two‐step multivariate Mendelian randomization study
Authors' conclusion
Our findings provide evidence for causal and independent effects of sex- and time-specific anthropometric traits on glycaemic variables, and highlight the importance of considering multiple obesity exposures at different time points in the life course.
Study context
- Population
- Europeans from the Early Growth Genetics Consortium, UK Biobank, GIANT Consortium and MAGIC; anthropometric traits (gestational variables, birth weight, childhood BMI, BMI, WHR, BMI-adjusted WHR) vs fasting glucose and insulin
- Outcome
- Fasting glucose and insulin
Methodological detailsunivariate and multivariate, two-step
- Univariate and multivariate
- Two-step
Main finding
As reported in the abstract
Causal associations of anthropometric traits with glycaemic traits
Females: increased birth weight causally decreased fasting insulin (betaIVW, 95% CI −0.11 to −0.03; p = 1.92 × 10-3), not glucose; annulled by adjusting for age at menarche
−0.07
Males: increased birth weight causally decreased fasting glucose (betaIVW, 95% CI −0.11 to −0.03; p = 3.22 × 10-4), not insulin
−0.07
Further findings
Time-specific (multivariate) analyses
- Independent effects of birth weight absent in females, more pronounced in males
- Independent effects of childhood BMI attenuated in both sexes; independent effects of adult traits differed by sex
Original publication
Sex‐ and time‐specific associations of obesity with glycaemic traits: A two‐step multivariate Mendelian randomization study. Diabetes Obes Metab. Published 19 January 2024. doi:10.
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