Effectiveness of surgical interventions for managing obesity in children and adolescents: A systematic review and meta‐analysis framed using minimal important difference estimates based on GRADE guidance to inform a clinical practice guideline
Authors' conclusion
Bariatric surgery demonstrated primarily moderate to very large improvements across diverse outcomes with limited evidence of AEs, albeit with low to moderate certainty of evidence.
Study context
- Population
- Children and adolescents with obesity (mean age <18 years); studies published January 2012–January 2022; 66% female
- Participants
- 6,128 children43 original studies
- Comparison
- Bariatric surgery vs baseline and control groups
- Outcome
- PROMs, cardiometabolic risk factors and anthropometry
Methodological detailsRandomized controlled trials (RCTs) and observational (controlled and uncontrolled) studies, outcomes and subgroups selected a priori by stakeholders, effects framed relative to minimal important differences (MIDs) and GRADE certainty, Most studies short-term follow-up (<18 months) only, patient-reported outcome measures (PROMs) measured in 12 (28%) studies, Uncontrolled single-arm observational (n = 49), controlled observational (n = 13) and RCT (n = 1) designs
- RCTs and observational (controlled and uncontrolled) studies
- Outcomes and subgroups selected a priori by stakeholders
- Effects framed relative to MIDs and GRADE certainty
- Most studies short-term follow-up (<18 months) only
- PROMs measured in 12 (28%) studies
- Uncontrolled single-arm observational (n = 49), controlled observational (n = 13) and RCT (n = 1) designs
Pooled result
As reported in the abstract
- Large improvements in health-related quality of life vs baseline and control groups
- Moderate to very large improvements in cardiometabolic risk factors vs baseline
- Large to very large improvements in BMIz vs baseline across all follow-up periods
- Low to moderate certainty of evidence
Safety
- Limited evidence of adverse events (AEs), most mild or non-specific; serious AEs uncommon
Original publication
Effectiveness of surgical interventions for managing obesity in children and adolescents: A systematic review and meta‐analysis framed using minimal important difference estimates based on GRADE guidance to inform a clinical practice guideline. Pediatr Obes. Published 3 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →