A meta‐analysis and polygenic score study identifies novel genetic markers for waist‐hip ratio in African populations
Authors' conclusion
The discovery of a novel locus for WHR and genetic signals for each trait and the assessment of polygenic score performance underscore the importance of conducting well-powered studies in diverse populations.
Study context
- Population
- African populations: ACCME cohort (n = ≈11,000) for discovery and polygenic score target analyses; Africa America Diabetes Mellitus (AADM) study (n = ≈5200) for replication and polygenic score validation
- Outcome
- Top loci associated with each trait in the meta-analysis
Methodological detailsdiscovery and replication cohorts, gene set analysis
- Discovery and replication cohorts
- Gene set analysis
Pooled result
As reported in the abstract
- Waist-hip ratio (WHR): CD36 rs3211826
- p = 5.90 × 10-12
- WHR adjusted for BMI: CD36 rs73709003
- p = 1.75 × 10-13
- Waist circumference: IFI27L1 rs59775050
- p = 2.66 × 10-08
- BMI: INPP4B rs2636629
- p = 1.44 × 10-09
- Height: HMGA1 rs6937622
- p = 1.40 × 10-15
- Novel variant rs7797157 near GNAT3, WHR
- p = 2.50 × 10-10
- Novel variant rs7797157 near GNAT3, WHR adjusted for BMI
- p = 2.66 × 10-11
Further pooled results
Best predictive polygenic scores by ancestry
- WHR, European ancestry
- R2 = 0.68%; p = 1.63 × 10-16
- WHR, multiethnic ancestry
- R2 = 0.06%; p = 1.29 × 10-02
- BMI, European ancestry
- R2 = 1.36%; p = 2.94 × 10-31
- BMI, multiethnic ancestry
- R2 = 1.12%; p = 3.52 × 10-25
- Height, European ancestry
- R2 = 3.16%; p = 2.95 × 10-73
- Height, African ancestry
- R2 = 4.16%; p = 1.75 × 10-96
- Height, African and Afro-Caribbean ancestry
- R2 = 2.67%; p = 4.35 × 10-62
Original publication
A meta‐analysis and polygenic score study identifies novel genetic markers for waist‐hip ratio in African populations. Obesity (Silver Spring). Published 1 October 2024. doi:10.
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