Adherence to the EAT ‐Lancet Diet, Genetic Susceptibility and Risk of Obesity and Obesity‐Related Morbidities: A Prospective Cohort Study
Main finding · Incident ORMs (Stubbendorff index)Result — go to the resultHazard ratio 0.85 95% CI 0.83–0.87Authors' conclusion
Greater adherence to the EAT-Lancet diet is associated with lower obesity prevalence and reduced risk of ORMs. This dietary pattern may partially attenuate genetic susceptibility to obesity, highlighting its potential as an effective strategy for preventing obesity and its related complications.
Study context
- Population
- UK Biobank participants; EAT-Lancet diet adherence from 24-h dietary recalls (Stubbendorff and Knuppel indices); genetic risk by polygenic risk scores (PRS) for body mass index (BMI) and waist-to-hip ratio (WHR)
- Participants
- 171,561 participants
- Exposure
- Higher vs lower adherence to the EAT-Lancet diet
- Outcome
- Obesity prevalence and incident obesity-related morbidities (ORMs)
- Follow-up
- median 11.9-years follow-up
Methodological detailsUK Biobank, multivariable logistic and Cox proportional hazards models
- UK Biobank
- Multivariable logistic and Cox proportional hazards models
Main finding
Incident ORMs (Stubbendorff index) · median 11.9 years
Hazard ratio
0.85
95% CI 0.83–0.87
Highest quartilevs Lowest quartile
HR 0.85 (95% CI 0.83–0.87)
As reported in the abstract
- Incident ORM cases
- 48 853
Observational data: associations, not effects.
Further findings
Interaction of diet index with BMI-PRS for ORMs
- Interaction diet index × BMI-PRS
- P for interaction = 0.014
- Low BMI-PRS and high diet adherence (lowest risk), HR
- 0.70; 95% CI 0.66-0.74
- Similar interaction for WHR-PRS; lowest risk with low genetic risk and high adherence
Knuppel index, subgroup and sensitivity analyses
- Results consistent for Knuppel index and robust across all subgroup and sensitivity analyses
Original publication
Adherence to the EAT ‐Lancet Diet, Genetic Susceptibility and Risk of Obesity and Obesity‐Related Morbidities: A Prospective Cohort Study. Diabetes Obes Metab. Published 7 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →