Association of Long‐Term Trajectories in Obesity Indices With Neuroimaging Metrics and Cognition: A Population‐Based Study
Authors' conclusion
Persistent central obesity is associated with adverse brain structural changes, and WC and WHR trajectories are associated with cognitive decline.
Study context
- Population
- Participants from the Kailuan cohort with ≥ 3 follow-up visits during 2006–2018
- Participants
- 1,114 participants
- Exposure
- Long-term trajectories in obesity indices (body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR)) and brain structure and cognition
- Outcome
- Brain structure and cognition by obesity-index trajectory
Methodological detailsgroup-based trajectory modelling, mediation analyses
- Group-based trajectory modelling
- Mediation analyses
Main finding
As reported in the abstract
β
- High-stable WC trajectory · grey matter volume (GMV)
- −0.331 (95% CI −0.522 to −0.139)
- High-stable WC trajectory · white-matter hyperintensity (WMH)
- 0.423 (95% CI 0.166–0.680)
- High-stable WC trajectory · cognition
- −0.909 (95% CI −1.701 to −0.116)
- High-stable WHR trajectory · cognition
- −0.543 (95% CI −1.034 to −0.052)
Observational data: associations, not effects.
Original publication
Association of Long‐Term Trajectories in Obesity Indices With Neuroimaging Metrics and Cognition: A Population‐Based Study. Diabetes Obes Metab. Published 8 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →