BMI, waist circumference, and waist-to-hip trajectories and all-cause, CVD, and cancer mortality by sex in people without diabetes
Main finding · Cancer mortality, BMI trajectory, femalesResult — go to the resultHazard ratio 1.76 95% CI 1.14–2.73Authors' conclusion
Sex differences were observed in the long-term impact of high BMI, waist circumference, and waist-to-hip ratio on mortality risks and lifespan in people without diabetes.
Study context
- Population
- People without diabetes, Atherosclerosis Risk in Communities Study
- Participants
- 7,601 people
- Exposure
- BMI, waist circumference and WHR trajectories, by sex
- Outcome
- All-cause, CVD and cancer mortality
Methodological detailslatent class trajectory analysis, propensity score matching, Cox proportional hazards regression
- Latent class trajectory analysis
- Propensity score matching
- Cox proportional hazards regression
Main finding
Cancer mortality, BMI trajectory, females
Hazard ratio
1.76
95% CI 1.14–2.73
Highvs Low
HR 1.76 (95% CI 1.14–2.73)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mean, years
| Outcome | High | Low |
|---|---|---|
| Mean lifespan of deceased males, waist circumference trajectory | 73.0 | 75.3 |
Mean lifespan of deceased males, waist circumference trajectory
- Shorter lifespan in high vs low waist circumference group (males)
Mean lifespan of deceased females
- Did not significantly differ across the trajectories
Original publication
BMI, waist circumference, and waist-to-hip trajectories and all-cause, CVD, and cancer mortality by sex in people without diabetes. Int J Obes (Lond). Published 9 April 2025. doi:10.
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