Netrin 4 is a novel cytokine associated with oxidative stress and insulin resistance in obese individuals
Authors' conclusion
NTN4 is associated with obesity-related IR.
Study context
- Population
- Healthy and overweight/obese women
- Participants
- 193 vs 211
- Exposure
- OW/OB women vs healthy women
- OW/OBn = 193
- Healthyn = 211reference
- Outcome
- Serum NTN4 concentration (ELISA)
Methodological detailspopulation-based cohort, bioinformatics analysis, intervention tests (cold exposure, acute exercise, lipid infusion, OGTT, EHC)
- Population-based cohort
- Bioinformatics analysis
- Intervention tests (cold exposure, acute exercise, lipid infusion, OGTT, EHC)
Main finding
As reported in the abstract
Circulating NTN4
- Individuals with OW/OB and IR had significantly elevated circulating NTN4
- Serum NTN4 significantly correlated with indicators of obesity, IR, sex hormone and glucose/lipid metabolism
Observational data: associations, not effects.
Further findings
GWAS and bioinformatics analysis
- NTN4 closely related to energy metabolism and OS
Original publication
Netrin 4 is a novel cytokine associated with oxidative stress and insulin resistance in obese individuals. Diabetes Res Clin Pract. Published 9 April 2025. doi:10.
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