Sex dimorphic associations between oxidative stress and adiposity in early childhood
Authors' conclusion
Oxidative stress levels were elevated in overweight/obesity children, and positively correlated with adiposity in males only, suggesting sex-dimorphic associations between oxidative stress and adiposity/obesity in early childhood.
Study context
- Population
- Children aged 4 years in the Shanghai Birth Cohort120 pairs
- Comparison
- Overweight/obesity vs optimal weight
- Outcome
- Oxidative stress (urinary 8-isoprostane) in relation to obesity/overweight and adiposity (BMI z-score, BFM, PBF)
- Follow-up
- Age 4 years
Main finding
As reported in the abstract
Urinary 8-isoprostane, males
P = 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Overweight/obese | Optimal weight | P value |
|---|---|---|---|
| Urinary 8-isoprostane, females · age 4 yearsSimilar in females | 1.74 ± 1.81 | 1.81 ± 0.94 | P = 0.26 |
Correlation of 8-isoprostane with adiposity, by sex
- Males: Body mass index (BMI) z-score r
- 0.34, P < .001
- Males: Body fat mass (BFM) r
- 0.28, P < .001
- Males: Percent body fat (PBF) r
- 0.26, P = .002
- Females: no correlation observed
Adjusted association per log unit increase in 8-isoprostane, males
- BMI z-score increase
- 0.72 (.31-1.13) (95% CI)
- BFM increase, kg
- 1.02 (0.12-1.19)
- PBF increase
- 3.09% (0.01%-6.17%)
- Adjusted for maternal and child factors
Original publication
Sex dimorphic associations between oxidative stress and adiposity in early childhood. Eur J Endocrinol. Published 5 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →