Prenatal oxidative stress and rapid infant weight gain
Authors' conclusion
We found an association between 8-iso-PGF2α, a lipid prenatal oxidative stress biomarker, and rapid infant weight gain, expanding our understanding of the developmental origins of obesity and cardiometabolic disease.
Study context
- Population
- Pregnant participants and their infants, NYU Children's Health and Environment Study425 with weight data
- Participants
- 541 participants
- Exposure
- Prenatal urinary oxidative stress biomarkers and infant weight outcomes
- Outcome
- Rapid infant weight gain (>0.67 increase in WAZ) between birth and later infancy
- Follow-up
- 8 or 12 month visit
Main finding
As reported in the abstract
Rapid infant weight gain, prenatal 8-iso-PGF2α (lipid biomarker), adjusted binary model
8-iso-PGF2α and rapid infant weight gain, aOR (95% CI 1.16, 1.78), p = 0.001
1.44
Observational data: associations, not effects.
Secondary outcomes
Rapid infant weight gain (>0.67 but ≤1.34 WAZ) vs ≤0.67 change in WAZ (reference), 8-iso-PGF2α, multinomial model
- aOR (95% CI 1.19, 2.05), p = 0.001
- 1.57
Very rapid infant weight gain (>1.34 WAZ) vs ≤0.67 change in WAZ (reference), 8-iso-PGF2α, multinomial model
- aOR (95% CI 1.02, 1.72), p < 0.05
- 1.33
Low birthweight
- Associations detected between 8-iso-PGF2α and low birthweight outcomes
Original publication
Prenatal oxidative stress and rapid infant weight gain. Int J Obes (Lond). Published 3 April 2023. doi:10.
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