Cardiovascular Outcomes and Mortality After Bariatric Surgery in Patients With Nonalcoholic Fatty Liver Disease and Obesity
Authors' conclusion
These findings suggest that BS was significantly associated with lower risk of major adverse cardiovascular events and all-cause mortality in patients with NAFLD and obesity.
Study context
- Population
- Adults with body mass index (BMI) ≥35 and nonalcoholic fatty liver disease (NAFLD) (without cirrhosis); Bariatric surgery (BS) between January 1, 2005, and December 31, 2021matched cohort
- Participants
- 4,687 vs 4,687
- Exposure
- Bariatric surgery vs nonsurgical care
- BSn = 4,687
- non-BSn = 4,687reference
- Outcome
- First incidence of new-onset heart failure (HF); composite cardiovascular events (unstable angina, MI or revascularization); composite cerebrovascular disease; composite of coronary artery procedures or surgeries
Methodological detailspopulation-based, 1:1 propensity-score matched, TriNetX platform, Follow-up ended August 31, 2022; data analysed September 2022
- Population-based
- 1:1 propensity-score matched
- TriNetX platform
- Follow-up ended August 31, 2022; data analysed September 2022
Main finding
As reported in the abstract
Primary outcomes
BS vs non-BSHazard ratio (95% CI)
New-onset HF
0.60(0.51–0.70)
Cardiovascular events
0.53(0.44–0.65)
Cerebrovascular events
0.59(0.51–0.69)
Coronary artery interventions
0.47(0.35–0.63)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| All-cause mortality | 0.56 (0.42–0.74) | |
| 0.512Hazard ratio (log scale) |
Outcomes by follow-up duration · 1, 3, 5, and 7 years
- Outcomes consistent at follow-up of 1, 3, 5 and 7 years
Original publication
Cardiovascular Outcomes and Mortality After Bariatric Surgery in Patients With Nonalcoholic Fatty Liver Disease and Obesity. JAMA Netw Open. Published 3 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →