Associations of obesity indices change with cardiovascular outcomes: a dose-response meta-analysis
Authors' conclusion
The effects of changes in weight and BMI on CVD outcomes were affected by age and cardiovascular health. Tailored weight management and avoidance of increased WC should be recommended.
Study context
- Population
- Studies of changes in weight, body mass index (BMI), waist circumference (WC), waist-to-hip ratio and waist-to-height ratio and cardiovascular disease (CVD) events, CVD-specific deaths and all-cause mortality122 articles
- Comparison
- Changes in obesity indices
- Outcome
- CVD events, CVD-specific deaths and all-cause mortality
Methodological detailsone-stage mixed-effects dose-response model, random-effects models, Searched MEDLINE, Embase, Web of Science, CINAHL and Scopus for articles published before January 8th, 2023
- One-stage mixed-effects dose-response model
- Random-effects models
- Searched MEDLINE, Embase, Web of Science, CINAHL and Scopus for articles published before January 8th, 2023
Pooled result
As reported in the abstract
CVD events, CVD-specific and all-cause mortality
- Weight change was negatively associated with deaths from CVD and any cause
- WC change elevated CVD-specific mortality; non-linear relationships confirmed adverse effects of increased WC on CVD-specific mortality
- Gains of 5 kg in weight and 1 kg/m² in BMI or more associated with elevated CVD events, especially among young adults and individuals without CVD
- Reductions of 5 kg in weight and 1 kg/m² in BMI or more associated with higher CVD-specific and all-cause deaths than increased counterparts, particularly among old adults and individuals with CVD
- Similar non-linear relationships between relative changes in weight and BMI and deaths from CVD and any cause
Original publication
Associations of obesity indices change with cardiovascular outcomes: a dose-response meta-analysis. Int J Obes (Lond). Published 9 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →