Associations of short‐term changes in obesity indices with all‐cause mortality and cardiovascular disease
Authors' conclusion
Short-term changes in obesity indices show complex mortality risks, urging personalized approaches beyond a simple weight loss focus.
Study context
- Population
- Participants of the MJ Health Centre with repeated obesity measures over 1, 3 or 5 years1-year study
- Participants
- 43,304 participants
- Exposure
- Short-term reduced or increased obesity indices vs stable
- Outcome
- All-cause mortality and CVD risk
- Follow-up
- Median 15.8, 13.9 and 12.3 years (1-, 3-, 5-year studies)
Methodological detailstime-dependent coefficient Cox regression, restricted cubic splines, multivariable linear regression
- Time-dependent coefficient Cox regression
- Restricted cubic splines
- Multivariable linear regression
Main finding
As reported in the abstract
All-cause and CVD mortality
- All-cause mortality negatively associated with short-term weight and BMI changes; greater reductions, poorer outcomes
- Short-term reduced weight and BMI vs stable: greater risk of all-cause mortality and cardiovascular disease (CVD)-specific mortality (5-year study only)
- 1- and 3-year reduced or 3-year increased waist circumference and waist to height ratio: higher all-cause and CVD deaths vs stable, respectively
Observational data: associations, not effects.
Further findings
Nonlinear relationships with all-cause mortality
- Lower cutoff values for short-term changes in obesity indices in predicting all-cause mortality
Framingham Risk Score / CVD profiles
- Decreased obesity indices significantly improved CVD profiles
Original publication
Associations of short‐term changes in obesity indices with all‐cause mortality and cardiovascular disease. Obesity (Silver Spring). Published 24 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →