The effectiveness of multidisciplinary weight loss interventions is associated with initial cardiorespiratory fitness in adolescents with obesity
Authors' conclusion
Initial CRF is associated with the success of MWLI in adolescents with obesity. Improving their aerobic fitness before starting a MWLI might be a promising strategy to optimize its benefits.
Study context
- Population
- Adolescents with obesity (aged 13.3 ± 1.38 years, 61.2% female, body mass index (BMI) 35.11 ± 5.16 kg/m²) in a 16-week multidisciplinary weight loss interventions (MWLI)
- Participants
- 165 adolescents
- Exposure
- Baseline VO2peak ≥3rd quartile vs first quartile vs interquartile range
- Outcome
- Change in total FM percentage (DXA)
- Follow-up
- T0 to T1 (16 weeks)
Methodological details16-week multidisciplinary weight loss intervention, pre–post (T0, T1)
- 16-week multidisciplinary weight loss intervention
- Pre–post (T0, T1)
Main finding
As reported in the abstract
Reduction in total FM percentage · T0 to T1
- VO2peak ≥ 3rd quartile vs First quartile: P < 0.001
- VO2peak ≥ 3rd quartile vs Interquartile range: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Reduction in BMI · T0 to T1VO2peak ≥ 3rd quartile vs First quartile · greater reduction with VO2peak ≥ 3rd quartile | P < 0.001 |
| Reduction in BMI · T0 to T1VO2peak ≥ 3rd quartile vs Interquartile range · greater reduction with VO2peak ≥ 3rd quartile | P < 0.05 |
Correlation of baseline VO2peak and VO2 at first ventilatory threshold with changes in body mass, BMI, total and visceral fat mass (FM) % and lean mass (LM) % · T0 to T1
- Positively correlated with reductions in body mass, BMI, total and visceral FM % and with increase in LM %
- P < 0.001
- Adjusted for age and gender
Original publication
The effectiveness of multidisciplinary weight loss interventions is associated with initial cardiorespiratory fitness in adolescents with obesity. Pediatr Obes. Published 23 June 2024. doi:10.
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