Effect of weight loss interventions on liver-related health in children and adolescents with obesity: a systematic review and meta-analyses
Authors' conclusion
The present results indicate improved overall liver status in response to weight loss interventions in this population, further studies remain however needed to clarify the effects of physical activity alone.
Study context
- Population
- Children and adolescents with obesity (aged 5–18 years)
- Participants
- 18,609 children145 studies
- Comparison
- Weight loss interventions on liver parameters
- Dietn = 26
- Medicationn = 24
- Multidisciplinaryn = 96
- Controlsn = 39reference
- Physical activityn = 16
- Supplementationn = 41
- Surgeryn = 15
- Outcome
- Circulating, imagery-related and histology-related liver parameters
Methodological detailsmeta-regression
- Meta-regression
Pooled result
As reported in the abstract
Liver parameters
Intervention arms with significant improvements in hepatic fat; no effect of physical activity interventions per meta-analysis
67%
Further pooled results
Meta-regression: NAFLD Activity Score
- Improvements in NAFLD Activity Score associated with degree of weight loss and BMI reduction
Original publication
Effect of weight loss interventions on liver-related health in children and adolescents with obesity: a systematic review and meta-analyses. Int J Obes (Lond). Published 8 July 2026. doi:10.
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