Risk factors and clinical nomogram for fatty pancreas in adults with obesity: a case-control study
Authors' conclusion
This study identified key risk factors and developed a validated prediction nomogram for FP in adults with obesity.
Study context
- Population
- People with obesity attending Qilu Hospital of Shandong University, January 1, 2020 to October 1, 2022; mean age 32.2 years, mean body mass index (BMI) 41.3 Kg/m²
- Participants
- 617 people
- Comparison
- Adults with obesity with vs without fatty pancreas
- Outcome
- Independent risk factors for FP (non-enhanced CT, pancreas/spleen ratio <0.7) and a prediction nomogram
Methodological detailsretrospective, bootstrap internal validation, temporal external validation
- Retrospective
- Bootstrap internal validation
- Temporal external validation
Main finding
As reported in the abstract
Independent factors for FP
Odds ratio (95% CI)P value
BMI
1.97(1.29–3.01)
P = 0.002DBP
1.55(1.03–2.33)
P = 0.035HDL
1.67(1.11–2.52)
P = 0.014HbA1c
1.99(1.19–3.34)
P = 0.009Observational data: associations, not effects.
Further findings
Prevalence of fatty pancreas (FP)
- Prevalence of FP
- 23.3% (144/617)
Nomogram predictive performance
- ROC analysis: nomogram (BMI, diastolic blood pressure (DBP), high-density lipoprotein (HDL), HbA1c) has moderate predictive performance
Blood glucose and lipids
- Partial differences in blood glucose and lipid in obesity with vs without FP
Original publication
Risk factors and clinical nomogram for fatty pancreas in adults with obesity: a case-control study. Int J Obes (Lond). Published 7 April 2026. doi:10.
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