Association of Insulin Resistance and Insulin Secretion Indices and Glucose Metrics From Continuous Glucose Monitoring in People With Obesity
Authors' conclusion
Our findings suggest that CGM metrics, in particular, the simplest metric, CGM mean, was associated with the degree of insulin resistance. Further research is needed to determine whether CGM mean could be a tool to identify normal glucose-tolerant individuals with obesity potentially at risk for progressing to prediabetes and diabetes, and whether its convergence with increased glycemic variability can further contribute to risk prediction of glycemic disorders.
Study context
- Population
- Individuals with obesity, with or without T2D, wearing a continuous glucose monitoring (CGM) device and undergoing a 2-h oral glucose tolerance test (OGTT); 27 also underwent a two-step hyperglycemic-euglycemic clamp27 with clamp
- Participants
- 37 individuals
- Exposure
- OB(+T2D) vs OB(-T2D)
- OB(+T2D)n = 17
- OB(-T2D)n = 20reference
- Outcome
- Relationship between free-living CGM glucose metrics and indices of insulin resistance and insulin secretion (OGTT and clamp)
Main finding
As reported in the abstract
- CGM mean vs GIR from clamp, all participants (inverse correlation)
- r = −0.82, P < 0.001
- CGM mean inversely correlated with insulin resistance indices (insulin sensitivity index from OGTT and GIR) in each group separately
- P < 0.01
- CGM mean negatively correlated with insulin secretion indices only when both groups analysed together
- P < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| CGM metrics (mean and glycemic variability indices)OB(+T2D) vs OB(-T2D) · higher in OB(+T2D) | P < 0.001 |
Original publication
Association of Insulin Resistance and Insulin Secretion Indices and Glucose Metrics From Continuous Glucose Monitoring in People With Obesity. Diabetes Care. Published 19 December 2025. doi:10.
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