Continuous Glucose Monitoring Metrics Are Associated With Metabolic Dysfunction–Associated Steatotic Liver Disease and Not Dysglycaemia in Adolescents With Obesity—A Pilot Study
Authors' conclusion
In adolescents with obesity, CGM-derived glycaemic variability metrics were associated with adiposity and MASLD, whereas conventional laboratory measures were not. These findings suggest that CGM may provide complementary information for metabolic phenotyping in paediatric obesity. Longitudinal studies are required to determine implications.
Study context
- Population
- Adolescents with obesity (age 12.9 ± 2.9 years; 29 boys; mean BMI SDS 2.25 ± 0.58) undergoing 15 days of continuous glucose monitoring (CGM), FPG, oral glucose tolerance testing (OGTT), HbA1c and metabolic comorbidity assessment
- Participants
- 39 adolescents
- Comparison
- Adolescents with MASLD vs without MASLD
- MASLDn = 5
- Outcome
- Median mean amplitude of glycaemic excursion (MAGE)
Main finding
As reported in the abstract
P = 0.019
Further findings
Mean of daily difference (MODD)
P = 0.062
Correlations of BMI SDS with CGM metrics
- BMI SDS vs glucose management indicator (GMI), ρ (p = 0.041)
- 0.34
- BMI SDS vs mean glucose, ρ (p = 0.041)
- 0.34
- BMI SDS vs continuous overall net glycaemic action (CONGA), ρ (p = 0.022)
- 0.38
- Fasting glucose, 2-h OGTT glucose and HbA1c showed no associations
Original publication
Continuous Glucose Monitoring Metrics Are Associated With Metabolic Dysfunction–Associated Steatotic Liver Disease and Not Dysglycaemia in Adolescents With Obesity—A Pilot Study. Pediatr Obes. Published 3 May 2026. doi:10.
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