Modelling and assessment of glucose‐lactate kinetics in youth with overweight, obesity and metabolic dysfunction‐associated steatotic liver disease: A pilot study
Authors' conclusion
Youth with MASLD showed a delayed glucose metabolism, possibly because of greater utilization of the underlying substrates. A 3-h OGTT may be used to assess lactate metabolism effectively.
Study context
- Population
- Overweight and obese adolescents (six girls); BMI 33 (29–37); 75 g oral glucose tolerance test (OGTT)6 girls
- Participants
- 23 participants
- Comparison
- MASLD vs no-MASLD
- Outcome
- Glucose-lactate kinetics during OGTT (oral glucose-lactate minimal model)
Main finding
As reported in the abstract
- Glucose peaks 30 min earlier than lactate
- p = .0019
- Glucose-before-lactate peak pattern present in no-MASLD
- p < .001
- Lactate production rate (LPR) peaks 30 min later in MASLD
- p = .02
- SID and fr correlation
- ρ = −0.55, p = .008
- SID correlation with BMI
- ρ = −0.45, p = .04
- Fr correlation with BMI
- ρ = 0.45; p = .03
Further findings
4 h vs 3 h OGTT protocol for parameter estimation
- Protocol duration did not influence the parameter estimates
Original publication
Modelling and assessment of glucose‐lactate kinetics in youth with overweight, obesity and metabolic dysfunction‐associated steatotic liver disease: A pilot study. Diabetes Obes Metab. Published 14 May 2024. doi:10.
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