Lipids & metabolic liver disease
Patients with MASLD exhibit in vivo changes in hepatic response to oral fructose consumption
Authors' conclusion
Following fructose consumption, patients with MASLD exhibited distinct patterns of change in phosphate metabolites, reflecting differences in hepatic metabolic responses.
Study context
- Population
- Overweight or obese patients without diabetes
- Participants
- 37 participants
- Comparison
- Patients with vs without MASLD after oral 75-g fructose challenge
- Outcome
- Changes in hepatic phosphate metabolites (31P-MRS) after oral fructose
- Follow-up
- 60 minutes after fructose
Main finding
As reported in the abstract
Hepatic phosphate metabolites after oral fructose
- Without MASLD: Phosphomonoesters (PME) rose from 15.5 ± 4.8 to 19.3 ± 5.1 within 15 minutes
- P = .033
- Without MASLD: Pi decreased during first 30 minutes then increased above baseline, from 10.2 ± 1.9 to 11.8 ± 2.8
- P = .037
- Without MASLD: ATP dropped within 15 minutes, from 21.8 ± 3.4 to 19.9 ± 4.0
- P = .018
- Without MASLD: ATP persistently lower after 60 minutes, 19.1 ± 4.1 vs baseline
- P = .006
Original publication
Patients with MASLD exhibit in vivo changes in hepatic response to oral fructose consumption. J Clin Endocrinol Metab. Published 20 March 2026. doi:10.
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