One-hour post-load glucose is associated with biopsy-proven metabolic dysfunction-associated steatotic liver disease in obese individuals
Authors' conclusion
Elevated 1h-PG levels increase the risk of MASLD and MASH in obese individuals. Early screening and management of MASLD are necessary, even in NGT individuals when 1h-PG levels are ≥8.6 mmol/l.
Study context
- Population
- Obese participants who underwent oral glucose tolerance tests (OGTT) and liver biopsy, Drum Tower Hospital, Nanjing University Medical School
- Participants
- 538 participants
- Exposure
- Normal glucose tolerance (NGT) 1h-PG High vs NGT 1h-PG Low
- Outcome
- Biopsy-proven MASLD and MASH (NASH Clinical Research Network scoring)
Methodological detailssingle-centre, biopsy-proven, Logistic regression analyses
- Single-centre
- Biopsy-proven
- Logistic regression analyses
Main finding
As reported in the abstract
NGT 1h-PG High vs NGT 1h-PG LowOdds ratio (95 % CI)
MASLD
3.27(1.32–8.09)
MASH
3.08(1.55–6.11)
Observational data: associations, not effects.
Further findings
Liver histology
- Elevated 1h-PG associated with hepatic steatosis, lobular inflammation and fibrosis
Mediation of 1h-PG–hepatic steatosis association by Matsuda index and disposition index (sequential)
- Share of total effect
- 14.23 %
- β
- 0.014 (95 % CI 0.002;0.035)
Original publication
One-hour post-load glucose is associated with biopsy-proven metabolic dysfunction-associated steatotic liver disease in obese individuals. Diabetes Metab. Published 5 December 2024. doi:10.
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