Associations of body size and morphology with cardiometabolic health in children: the contribution of genetic factors
Authors' conclusion
BMI and waist circumference provide information on cardiometabolic health that is not less accurate than that provided by more comprehensive anthropometric indices. These associations reflect causal associations between obesity and cardiometabolic disorders rather than only shared genetic associations. Measuring obesity is important for monitoring cardiometabolic risks and can be accomplished using simple indicators at the population level.
Study context
- Population
- Twins aged 3 to 18 years living in the Autonomous Region of Madeira, Portugal (51% girls)
- Participants
- 216 twin pairs
- Outcome
- Associations of anthropometric indicators with cardiometabolic health indicators
Methodological detailsgenetic twin modeling
- Genetic twin modeling
Main finding
As reported in the abstract
- Anthropometric indicators positively associated with blood pressure and TG, inversely with HDL-C
- Associations with glucose, LDL-C, total cholesterol and heart rate close to zero
- BMI and waist circumference showed similar or slightly higher absolute correlations with cardiometabolic indicators vs other anthropometric indices
- Additive genetic and unique environmental correlations at the same level as trait correlations
Original publication
Associations of body size and morphology with cardiometabolic health in children: the contribution of genetic factors. Obesity (Silver Spring). Published 5 December 2024. doi:10.
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