Butyrylcholinesterase as a potential biomarker of metabolic imbalances in Afro-descendant populations
Authors' conclusion
This study revealed higher BChE activity and TDM2 prevalence in Afro-Brazilian populations compared to Euro-Brazilians, and these differences correlate with non-genetic factors. The BCHE genetic variants investigated showed no robust associations after correction for multiple testing, suggesting that their effects on metabolic traits may be subtle and context-dependent.
Study context
- Population
- Afro-Brazilian individuals from two quilombos in southern Brazil and Euro-Brazilian individuals from the same region
- Participants
- 198 vs 114
- Exposure
- Afro-Brazilian Quilombolas vs Euro-Brazilians
- Afro-Braziliansn = 198
- Euro-Braziliansn = 114reference
- Outcome
- BChE activity (Ellman method) and BCHE genetic variants (−116, A, K)
Methodological detailsVariants genotyped by PCR-SSP; age- and sex-adjusted regression models
- Variants genotyped by PCR-SSP; age- and sex-adjusted regression models
Main finding
As reported in the abstract
BChE activity
Quilombola
3.71
mean · U/mL
- Butyrylcholinesterase (BChE) activity significantly higher in people with TDM2 and/or obesity
- P = 0.016
Observational data: associations, not effects.
Original publication
Butyrylcholinesterase as a potential biomarker of metabolic imbalances in Afro-descendant populations. Int J Obes (Lond). Published 13 May 2026. doi:10.
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