Body Mass Index and All‐Cause, Cancer, and Cardiovascular Mortality in Adults Aged 16–50 Years With and Without Type 2 Diabetes: An Analysis of Primary Care Records in England
Authors' conclusion
The excess risk of mortality associated with T2D was greatest at lower BMI, where absolute risk estimates were high.
Study context
- Population
- Adults aged 16–50 years with and without T2D, primary care records in England (Clinical Practice Research Datalink (CPRD)); median age at T2D diagnosis 44.0 yearsmatched cohort
- Participants
- 384,787 adults
- Exposure
- T2D vs no T2D across body mass index (BMI)
- T2Dn = 86,606
- Outcome
- All-cause, cancer and CVD mortality by BMI
- Follow-up
- 10-year cumulative incidence
Methodological detailsmatched 1: up to 10 by year of birth, sex and general practice, CPRD linked to Hospital Episode Statistics (HES) and Office for National Statistics (ONS) mortality records, flexible parametric survival models, competing risk approaches
- Matched 1: up to 10 by year of birth, sex and general practice
- CPRD linked to HES and ONS mortality records
- Flexible parametric survival models
- Competing risk approaches
Main finding
As reported in the abstract
BMI and all-cause and cause-specific mortality
U-shaped association; nadir at BMI in T2D
29.3 kg/m²
U-shaped association; nadir at BMI without T2D
27.2 kg/m²
Observational data: associations, not effects.
Further findings
| Outcome | T2D | Without T2D |
|---|---|---|
| 10-year cumulative incidence of all-cause mortality at age 45 years and BMI 20 kg/m² | 17.3% (95% CI 13.9%–20.6%) | 4.4% (95% CI 4.0%–4.7%) |
Original publication
Body Mass Index and All‐Cause, Cancer, and Cardiovascular Mortality in Adults Aged 16–50 Years With and Without Type 2 Diabetes: An Analysis of Primary Care Records in England. Diabetes Obes Metab. Published 12 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →