Association of Serum Uric Acid With All-Cause and Cardiovascular Mortality in Diabetes
Authors' conclusion
This study indicated that higher SUA levels were associated with increased risks of all-cause and CVD mortality in diabetes. Interventional studies are needed to elucidate the health effect of treatments to lower SUA levels.
Study context
- Population
- Patients with diabetes from US National Health and Nutritional Examination Survey (NHANES) 1999–2018; mortality via linkage to national death records through 31 December 2019
- Participants
- 7,101 patients57,926 person-years
- Comparison
- Highest vs lowest serum uric acid (SUA) quintile
- Outcome
- All-cause and CVD mortality
Methodological detailsweighted Cox proportional hazards regression, fully adjusted model
- Weighted Cox proportional hazards regression
- Fully adjusted model
Pooled result
As reported in the abstract
Each group vs lowest SUA quintileEstimate (95% CI)
Highest SUA quintile
HR (all-cause mortality) 1.28(1.03–1.58)
Highest SUA quintile
HR (CVD mortality) 1.41(1.03–1.94)
- Weighted mean SUA
- 5.7 mg/dL
- Deaths
- 1,900
- Cardiovascular disease (CVD) deaths
- 674
Further pooled results
Meta-analysis: mortality per 1 mg/dL increment of SUA
- Pooled HR, all-cause mortality
- 1.08 (95% CI 1.05, 1.11)
- Pooled HR, CVD mortality
- 1.05 (95% CI 1.03, 1.06)
- 13 cohort studies
Original publication
Association of Serum Uric Acid With All-Cause and Cardiovascular Mortality in Diabetes. Diabetes Care. Published 9 December 2022. doi:10.
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