Fibrosis-4 stage of liver fibrosis predicts cardiovascular outcomes in acute coronary syndrome patients with and without type 2 diabetes mellitus
Authors' conclusion
Liver fibrosis staged by FIB-4 was correlated with an increased risk of MACCE, mortality, and MI in ACS patients who underwent PCI with and without T2DM. FIB-4 index may help risk stratification of ACS patients independent of T2DM status.
Study context
- Population
- Acute coronary syndrome (ACS) patients undergoing PCI, with and without T2D
- Participants
- 6,563 patients
- Exposure
- FIB-4 categories: <1.45 vs 1.45-3.25 vs ≥3.25
- Outcome
- MACCE
- Follow-up
- median 2.4-year follow-up
Main finding
As reported in the abstract
Total major adverse cardiac and cerebrovascular events (MACCE) events
270
Observational data: associations, not effects.
Further findings
Mortality and MI
- Intermediate or high FIB-4 scores significantly associated with elevated risk of mortality and MI
Ischemic stroke
- Intermediate or high FIB-4 scores not associated with ischemic stroke
Subgroups with and without T2D
- Results consistent in subgroups with and without T2D
Safety
Major bleeding · median 2.4-year follow-up
- Total major bleeding events
- 194
- Intermediate or high FIB-4 scores not associated with major bleeding
Original publication
Fibrosis-4 stage of liver fibrosis predicts cardiovascular outcomes in acute coronary syndrome patients with and without type 2 diabetes mellitus. Diabetes Res Clin Pract. Published 9 December 2022. doi:10.
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