Maximum stress hyperglycemia ratio within the first 24 h of admission predicts mortality during and after the acute phase of acute coronary syndrome in patients with and without diabetes: A retrospective cohort study from the MIMIC-IV database
Authors' conclusion
The maximum SHR was significantly associated with mortality in patients with ACS hospitalized in the ICU. However, caution is warranted if it is used for predicting mortality after 30 days in patients with diabetes.
Study context
- Population
- Patients with acute coronary syndrome (ACS) hospitalised in the intensive care unit (ICU), with and without diabetes, MIMIC-IV database
- Participants
- 2,668 patients
- Exposure
- Maximum vs first stress hyperglycemia ratio for predicting mortality
- Outcome
- In-hospital and 1-year mortality
Methodological detailsMIMIC-IV database, landmark analysis at 30 days
- MIMIC-IV database
- Landmark analysis at 30 days
Main finding
As reported in the abstract
Mortality
In-hospital mortality
4.7 %
1-year mortality
13.2 %
Observational data: associations, not effects.
Further findings
Maximum stress hyperglycemia ratio (SHR) and mortality within 30 days (landmark analysis)
- Maximum SHR was a risk factor for mortality within 30 days regardless of diabetes
- Landmark analysis
Maximum SHR and mortality after 30 days, patients with diabetes
- No longer associated with mortality after adjustment; HR per 1-point increment
- 1.237 (95 % CI 0.854-1.790)
- Landmark analysis
- Adjusted
Original publication
Maximum stress hyperglycemia ratio within the first 24 h of admission predicts mortality during and after the acute phase of acute coronary syndrome in patients with and without diabetes: A retrospective cohort study from the MIMIC-IV database. Diabetes Res Clin Pract. Published 1 February 2024. doi:10.
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