Assessment of stress hyperglycemia ratio to predict all-cause mortality in patients with critical cerebrovascular disease: a retrospective cohort study from the MIMIC-IV database
Main finding · In-hospital mortalityResult — go to the resultHazard ratio 1.35 95% CI 1.23–1.48Authors' conclusion
SHR serves as an independent risk factor for in-hospital mortality in cerebrovascular disease patients in the ICU. Adding SHR to existing models enhances their predictive performance, offering clinical value in the identification of high-risk patients.
Study context
- Population
- Critically ill patients with cerebrovascular disease in the intensive care unit (ICU), MIMIC-IV database; mean age 70.55 ± 14.59 years, 49.61% female
- Participants
- 2,461 patients
- Exposure
- Stress hyperglycemia ratio (SHR) per SD increase
- Outcome
- In-hospital mortality
Methodological detailsMIMIC-IV database
- MIMIC-IV database
Main finding
As reported in the abstract
Hazard ratio
1.35
95% CI 1.23–1.48
SHR per SD increase
HR 1.35 (95% CI 1.23–1.48)
Per SD increase, as printed
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| ICU mortality | 1.37 (1.21–1.54) | |
| 0.512Hazard ratio (log scale) |
Dose-response (restricted cubic spline)
- Risk of death increased approximately linearly when SHR exceeded
- 0.77-0.79
Subgroups by diabetes
- Association more pronounced in non-diabetic individuals
Model performance
- Adding SHR to existing models improved discrimination and reclassification
Original publication
Assessment of stress hyperglycemia ratio to predict all-cause mortality in patients with critical cerebrovascular disease: a retrospective cohort study from the MIMIC-IV database. Cardiovasc Diabetol. Published 7 February 2025. doi:10.
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