Incidence of T2DM and the role of baseline glycaemic status as a determinant in a metropolitan population in northern Madrid (Spain)
Authors' conclusion
Our incidence of T2DM is consistent with that reported elsewhere in Spain. While baseline iIGT and IFG-IGT behaved a primary effect for progression to T2DM, iIFG showed a trend in this direction.
Study context
- Population
- Adult population of Madrid (northern Madrid metropolitan population), Spain659 pre-T2D
- Participants
- 1,219 participants
- Exposure
- Pre-T2D categories vs normoglycaemia
- Normoglycaemian = 560reference
- iIFGn = 418
- iIGTn = 70
- IFG-IGTn = 171
- Outcome
- Incidence of T2D (defined by FPG or HbA1c or use of glucose-lowering medication) and effect of baseline pre-T2D on progression to T2D
- Follow-up
- 7.26 years
Methodological detailsCox model with normoglycaemia as reference category
- Cox model with normoglycaemia as reference category
Main finding
As reported in the abstract
Incident T2D
Normoglycaemic
5.60
CI 3.55–8.41 · per 1000 person-years
Hazard ratio (95% CI)
iIGTvs Normoglycaemic
3.96(1.93–8.10)
IFG-IGTvs Normoglycaemic
3.42(1.92–6.08)
iIFGvs Normoglycaemic
1.67(0.96–2.90)
- Unadjusted T2D incidence, whole population (per 1000 person-years)
- 11.21 (95 %CI, 9.09-13.68)
- Unadjusted T2D incidence, all pre-T2D participants (per 1000 person-years)
- 16.28 (12.78-20.43)
Observational data: associations, not effects.
Further findings
Obesity and incident T2D
- HR for obesity
- 2.50 [1.30-4.86]
Original publication
Incidence of T2DM and the role of baseline glycaemic status as a determinant in a metropolitan population in northern Madrid (Spain). Diabetes Res Clin Pract. Published 1 February 2024. doi:10.
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