One-hour glucose–defined metabolic phenotypes in youth with obesity: early β-cell impairment across the spectrum of dysglycemia
Authors' conclusion
A 1-hour glucose ≥ 155 mg/dL identifies a metabolically distinct phenotype with reduced insulin sensitivity and early β-cell dysfunction despite normal glucose tolerance
Study context
- Population
- Children and adolescents with obesity who underwent an oral glucose tolerance test (OGTT) at a tertiary center
- Participants
- 726 children
- Exposure
- NGT-High vs NGT-Low
- Outcome
- OGTT-derived insulin sensitivity and β-cell function, NGT-High vs NGT-Low
Methodological detailssingle tertiary centre
- Single tertiary centre
Main finding
As reported in the abstract
| Group | Value | Matsuda index | Insulin AUC (µIU/mL × min) |
|---|---|---|---|
| NGT-High | 1.59 | 1.59 | 19,845 |
| NGT-Low | 2.34 | 2.34 | 13,048 |
Value
NGT-High1.59
NGT-Low2.34
Matsuda index
NGT-High1.59
NGT-Low2.34
Insulin AUC (µIU/mL × min)
NGT-High19,845
NGT-Low13,048
- NGT-High vs NGT-Low: P < 0.001 — lower insulin sensitivity in NGT-High
- NGT-High vs NGT-Low: P < 0.001 — greater insulin exposure in NGT-High
Observational data: associations, not effects.
Further findings
Insulin peak timing
- Delayed insulin peak timing in impaired glucose tolerance (IGT) and advanced dysglycemia
Discrimination and determinants of dysglycemia
- FPG: highest discriminatory performance (AUC)
- 0.797
- HbA1c and ISSI-2 independently associated with dysglycemia
Original publication
One-hour glucose–defined metabolic phenotypes in youth with obesity: early β-cell impairment across the spectrum of dysglycemia. Diabetes Res Clin Pract. Published 4 July 2026. doi:10.
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