Effectiveness of dietary interventions in individuals with diabetes for preventing and healing chronic wounds; a systematic review with meta‐analysis
Authors' conclusion
There is low-quality evidence that nutrient supplementation improves wound healing. Nutrition education may have a role in enhancing wound size reduction. Further studies are needed using robust methodologies to comprehensively determine the effectiveness of nutrition interventions for wound healing.
Study context
- Population
- Individuals with diabetes and a chronic wound; all included studies in diabetes-related foot ulcer populations23 studies
- Comparison
- Nutrition interventions for chronic wounds in diabetes
- Outcome
- Mean wound size at follow-up
- Follow-up
- follow-up
Methodological detailsrandom-effects meta-analysis, RoB 2 and ROBINS quality appraisal, GRADE certainty assessment, 5 databases and 4 clinical trial registries searched
- Random-effects meta-analysis
- RoB 2 and ROBINS quality appraisal
- GRADE certainty assessment
- 5 databases and 4 clinical trial registries searched
Pooled result
As reported in the abstract
Wound size with nutrient supplements
Nutrient supplementsWMD (95% CI)P value
Wound width
−0.466(−0.724 to −0.208)
P = 0.0004- Wound depth
- MWD −0.200 (95% CI −0.364 to −0.035); P = 0.0172
- Wound length
- −0.443 (95% CI −0.841 to −0.045); P = 0.0292
- Heterogeneity I2
- 56%-68%
Further pooled results
Nutrition education
- Significant wound size reduction
- n = 1 study
- Significant improvement in proportion of people healed
- n = 1 study
- 2 studies
Original publication
Effectiveness of dietary interventions in individuals with diabetes for preventing and healing chronic wounds; a systematic review with meta‐analysis. Diabet Med. Published 9 July 2025. doi:10.
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