Diabetes complications

Non-pharmacological interventions to improve cardiovascular risk factors in people with diabetic foot disease: A systematic review and meta-analysis

Diabetes Res Clin PractPublished Systematic review and meta-analysis of randomised controlled trials

Authors' conclusion

Non-pharmacological interventions show promise in improving CVD risk in diabetic foot disease.

Study context

Population
People with T1D or T2D and current or previous diabetic foot disease20 studies
Comparison
Non-pharmacological interventions
Outcome
Change in CVD risk factors
Methodological detailsrandom effects meta-analyses, narrative syntheses, Databases and trials registers searched from inception to December 6th 2023
  • Random effects meta-analyses
  • Narrative syntheses
  • Databases and trials registers searched from inception to December 6th 2023

Pooled result

As reported in the abstract

CVD risk factors · post-intervention
  • Significant post-intervention changes in FPG, serum insulin, insulin sensitivity and resistance, HbA1c, TG, total cholesterol, LDL-C and C-reactive protein
  • No effects in very low- or HDL-C or BMI

Original publication

Non-pharmacological interventions to improve cardiovascular risk factors in people with diabetic foot disease: A systematic review and meta-analysis. Diabetes Res Clin Pract. Published 24 February 2024. doi:10.1016/j.diabres.2024.111590

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