Young adults with type 2 diabetes experience high rates of Level 3 Hypoglycemia: A subgroup analysis of the Real-World iNPHORM cohort
Authors' conclusion
Our results suggest that young adults with T2D are at particularly high risk of Level 3 hypoglycemia, with attributes that differ from those of the traditional middle-aged cohort.
Study context
- Population
- Adults with T2D in a one-year U.S.-wide real-world dataset
- Participants
- 207 vs 436
- Comparison
- Young adults vs middle-aged adults
- Young adultsn = 207
- Middle-aged adultsn = 436reference
- Primary endpoint
- Incidence proportion and rate of self-reported Level 3 hypoglycemia
- Follow-up
- one-year follow-up
Methodological detailsone-year U.S.-wide T2D dataset, retrospective and prospective data, age group-stratified multivariable negative binomial regression
- One-year U.S.-wide T2D dataset
- Retrospective and prospective data
- Age group-stratified multivariable negative binomial regression
Primary result
As reported in the abstract
Level 3 hypoglycemia · follow-up
Incidence proportion
twofold higher (P < 0.001)
Young adults
Annualized rate
fivefold higher (P < 0.001)
Young adults
Further findings
| Outcome | Incidence | P value |
|---|---|---|
| Level 3 hypoglycemia events requiring medical assistance · baseline | threefold higher | P < 0.001 |
| Hypoglycemia fear · follow-upGreater with young adults | P < 0.001 |
Characteristics and risk factors
- Distinct sociodemographics, health, lifestyle, diabetes history and therapy/technology use, and unique risk factors for Level 3 hypoglycemia frequency in young adults
Original publication
Young adults with type 2 diabetes experience high rates of Level 3 Hypoglycemia: A subgroup analysis of the Real-World iNPHORM cohort. Diabetes Res Clin Pract. Published 6 May 2025. doi:10.
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