Plasma metabolite profile of legume consumption and future risk of type 2 diabetes and cardiovascular disease
Authors' conclusion
This study identified a set of 40 metabolites associated with legume consumption and with a reduced risk of T2D development in a Mediterranean population at high risk of cardiovascular disease.
Study context
- Population
- PREDIMED participants with baseline metabolomic data, Mediterranean population at high cardiovascular disease (CVD) risk; mean age 67 years, 57.6% women1,522 validation subset
- Participants
- 1,833 participants
- Exposure
- Legume metabolite profile and incident T2D and CVD
- Outcome
- Incident T2D and CVD by legume metabolite profile
Methodological detailsmetabolomics, internal validation subset, elastic net regression, multivariable Cox regression, Plasma metabolites by liquid chromatography-tandem mass spectrometry; 382 known metabolites tested
- Metabolomics
- Internal validation subset
- Elastic net regression
- Multivariable Cox regression
- Plasma metabolites by liquid chromatography-tandem mass spectrometry; 382 known metabolites tested
Main finding
As reported in the abstract
Legume metabolite profile and incident T2D and CVD · over follow-up
Metabolites negatively associated with legume consumption
22
Metabolites positively associated with legume consumption
18
Incident T2D, HR per 1 SD of profile
0.75
95% CI 0.61–0.94p = 0.017
Incident CVD, HR per 1 SD of profile
1.01
95% CI 0.86–1.19p = 0.817
Observational data: associations, not effects.
Original publication
Plasma metabolite profile of legume consumption and future risk of type 2 diabetes and cardiovascular disease. Cardiovasc Diabetol. Published 20 January 2024. doi:10.
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