Type 2 diabetes subphenotypes are associated with differential outcomes after metabolic and bariatric surgery: An international multicentre retrospective cohort study
Authors' conclusion
T2D subphenotypes respond differently to T2D remission after MBS with SIDD showing a significantly lower remission rate than MOD and SIRD at 2 years. Considering metabolic status in treatment decisions may improve patient outcomes.
Study context
- Population
- People with T2D undergoing metabolic and bariatric surgery (MBS) at 4 clinical centres, retrospectively assigned to T2D subphenotypes
- Participants
- 233 people
- Exposure
- T2D subphenotypes: Severe insulin-deficient diabetes (SIDD) vs MOD vs severe insulin-resistant diabetes (SIRD)
- Outcome
- T2D remission
- Follow-up
- 2 years
Methodological detailsinternational, multicentre, 4 clinical centres
- International
- Multicentre
- 4 clinical centres
Main finding
As reported in the abstract
Diabetes remission
P < 0.001
Observational data: associations, not effects.
Secondary outcomes
Baseline MASH prevalence (intraoperative liver biopsy)
| Outcome | MOD | SIRD | SIDD | P value |
|---|---|---|---|---|
| BMISIDD vs MOD and SIRD · lower BMI in SIDD | — not stated in the abstract | — not stated in the abstract | 38.3 kg/m² | P < 0.001 |
| Beta-cell function (HOMA2-%B)SIDD vs MOD and SIRD · worse beta-cell function in SIDD | — not stated in the abstract | — not stated in the abstract | 92.4 | P = 0.010 |
| HOMA2-IRSIRD vs MOD and SIDD · highest HOMA2-IR in SIRD | — not stated in the abstract | 6.0 ± 3.4 | — not stated in the abstract | P < 0.001 |
— not stated in the abstract
%TWL
- %TWL was similar across subphenotypes
Original publication
Type 2 diabetes subphenotypes are associated with differential outcomes after metabolic and bariatric surgery: An international multicentre retrospective cohort study. Diabetes Obes Metab. Published 8 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →