Genetic variants in the MC4R gene and risk of obesity/overweight: A systematic review and meta‐analysis
Authors' conclusion
The present study confirms the high association of rs17782313 and rs12970134 with obesity and overweight in all age groups and geographic regions. However, further functional studies and high-population research on other MC4R SNPs must validate their role.
Study context
- Population
- Human case-control/cohort studies with MC4R genotype distributions, any geographic region and age; PubMed, Web of Science and Scopus up to June 202239 studies
- Participants
- 43,697 vs 52,272
- Comparison
- MC4R polymorphism genotypes and overweight/obesity risk
- Overweight and obese casesn = 43,697
- Normal weightsn = 52,272reference
- Outcome
- Association of MC4R polymorphisms with overweight/obesity risk (pooled ORs in different genetic models)
Methodological detailsrandom-effects model, subgroup analysis by geographic region and age group, PRISMA, Risk of bias for individual studies not assessed, Limited by restricted racial diversity, exclusion of environmental factors, incomplete data and limited access to certain articles
- Random-effects model
- Subgroup analysis by geographic region and age group
- PRISMA
- Risk of bias for individual studies not assessed
- Limited by restricted racial diversity, exclusion of environmental factors, incomplete data and limited access to certain articles
Pooled result
As reported in the abstract
Overweight/obesity risk, homozygous model, mixed-age populations
Odds ratio (95% CI)
rs17782313 homozygous model
1.73(1.51–1.98)
rs12970134 homozygous model
1.74(1.29–2.35)
Further pooled results
Subgroup analysis by geographic region
- rs17782313 and rs12970134 more strongly linked to overweight and obesity in Asian and European populations
Original publication
Genetic variants in the MC4R gene and risk of obesity/overweight: A systematic review and meta‐analysis. Diabetes Obes Metab. Published 30 April 2025. doi:10.
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