The interplay between the adrenergic system and obesity: a systematic review
Authors' conclusion
Overall, this systematic review highlights the complex interplay between catecholamines and obesity. It synthesizes current evidence and identifies key research gaps, thus providing valuable insights to guide future biomedical research and clinical practice.
Study context
- Population
- Adults with obesity in observational or interventional studies reporting plasma or urinary adrenaline and/or noradrenaline concentrations; PubMed, Web of Science and Scopus searched until June 2023
- Participants
- 2,588 adults35 studies
- Comparison
- Adults with obesity vs lean counterparts
- Obesityn = 1,617
- Outcome
- Adrenergic system in obesity
Pooled result
As reported in the abstract
- Hyperadrenergic state with obesity: higher noradrenaline and lower adrenaline plasma concentrations, blunted response to sympathetic stimuli vs lean counterparts (some heterogeneity across studies)
- Adrenergic overdrive seems more pronounced with obesity-associated comorbidities, except hypertension
- Abdominal fat weight loss interventions reduce baseline noradrenaline levels and restore impaired sympathetic response
Original publication
The interplay between the adrenergic system and obesity: a systematic review. Int J Obes (Lond). Published 11 October 2025. doi:10.
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