Association between overweight and obesity determined by body mass index and overall survival in patients with metastatic prostate cancer: a meta-analysis
Pooled result · OSResult — go to the resultPooled adjusted hazard ratio 0.79 95% CI 0.73–0.85Authors' conclusion
Patients with mPC who have overweight or obesity, as defined by BMI, are associated with improved overall survival, particularly in those with mCRPC.
Study context
- Population
- Patients with metastatic prostate cancer (mPC); PubMed, Web of Science and Embase searched until February 202515 studies in 13 articles
- Participants
- 18,280 patients
- Comparison
- Overweight/obesity vs normal weight
- Outcome
- Overall survival (OS)
Pooled result
OS
Pooled adjusted hazard ratio
0.79
95% CI 0.73–0.85
Overweight/obesityvs Normal weight
pooled adjusted HR 0.79 (95% CI 0.73–0.85)
As reported in the abstract
Further pooled results
Overall survival (OS) by body mass index (BMI) category
| Pooled adjusted HR (95% CI) | ||
|---|---|---|
| Overweight | 0.81 (0.75–0.87) | |
| Obesity | 0.78 (0.67–0.90) | |
| 0.512Pooled adjusted hazard ratio (log scale) |
OS in metastatic castration-resistant prostate cancer (mCRPC) subgroup
| HR (95% CI) | ||
|---|---|---|
| OverweightAssociation more pronounced in mCRPC | 0.78 (0.71–0.85) | |
| ObesityAssociation more pronounced in mCRPC | 0.73 (0.59–0.90) | |
| 0.512Hazard ratio (log scale) |
OS per 1-unit increase in BMI
- Improvement in OS per 1-unit BMI increase
- 4% (95% CI 1.0-8.0%)
Original publication
Association between overweight and obesity determined by body mass index and overall survival in patients with metastatic prostate cancer: a meta-analysis. Int J Obes (Lond). Published 15 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →