Biological Pathways of Strength Preservation During Calorie Restriction‐Induced Weight Loss Among Adults Without Obesity
Authors' conclusion
These findings highlight molecular pathways and genes supporting strength retention during caloric restriction-induced weight loss.
Study context
- Population
- Healthy adults without obesity; transcriptomics in a subset who provided skeletal muscle samples42 in transcriptomics subset
- Comparison
- Caloric restriction vs ad libitum intake
- Primary endpoint
- Association of change in knee extensor strength with gene expression change, controlling for whole-body mass change
- Follow-up
- First 12 months
Methodological details2-year, randomized controlled, transcriptomic profiling in skeletal muscle subset
- 2-year
- Randomized controlled
- Transcriptomic profiling in skeletal muscle subset
Primary result
As reported in the abstract
Genes associated with strength change, adjusted for whole-body mass change · 12 months
- Genes significantly associated with change in strength after accounting for whole-body mass change, incl. HSP90AA1 and EIF3A
- 151
Original publication
Biological Pathways of Strength Preservation During Calorie Restriction‐Induced Weight Loss Among Adults Without Obesity. Obesity (Silver Spring). Published 1 September 2026. doi:10.
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