Proportion of caloric restriction‐induced weight loss as skeletal muscle
Authors' conclusion
Nonelderly males and females with overweight and obesity experience respective reductions in SM mass with voluntary CR in the absence of a structured exercise program of about 2 to 2.5 kg and 1 to 1.5 kg per 10-kg weight loss, respectively. These estimates are predicted to be influenced by interactions between age and body mass index in males, a hypothesis that needs future testing.
Study context
- Population
- Healthy nonexercising adults with whole-body skeletal muscle (SM) mass measured by MRI; validation in two longitudinal calorie restriction (CR) studies (12 to 14 weeks, n = 74; 12 months, n = 26)model development
- Participants
- 897 participants
- Comparison
- Males vs females
- Malesn = 415
- Femalesn = 482
- Outcome
- Model-predicted change in SM mass relative to change in body weight (ΔSM/Δbody weight) with voluntary CR
Methodological detailsMRI-measured whole-body SM mass, longitudinal validation samples
- MRI-measured whole-body SM mass
- Longitudinal validation samples
Performance
As reported in the abstract
Model-predicted ΔSM/Δbody weight (representative model)
Males
0.26
mean · SE 0.013
Females
0.14
mean · SE 0.007
P < 0.001
Further findings
Actual mean proportion of weight loss as SM in longitudinal studies (12–14 weeks / 12 months)
- Males, 12–14-week / 12-month study (mean ± SE)
- 0.23 ± 0.02/0.20 ± 0.06
- Females, 12–14-week / 12-month study (mean ± SE)
- 0.10 ± 0.02/0.17 ± 0.03
- Similar to model-predicted values
Original publication
Proportion of caloric restriction‐induced weight loss as skeletal muscle. Obesity (Silver Spring). Published 8 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →