Abdominal skeletal muscle quality and quantity are independently and jointly associated with cardiometabolic health in children
Authors' conclusion
Both high IMAAT and low AMT are associated to poor cardiometabolic health already in childhood.
Study context
- Population
- Children from two cohorts: 114 children (10.6 ± 1.1 y, 54% girls) and 56 children (11.3 ± 1.5 y, 39% girls); Intermuscular abdominal adipose tissue (IMAAT) and AMT measured by MRItwo cohorts: 114 and 56
- Outcome
- Associations of IMAAT and AMT with cardiometabolic health (TG/HDL, MAP, HOMA-IR, MetSynd)
Methodological detailstwo cohorts
- Two cohorts
Main finding
As reported in the abstract
- IMAAT associated with higher MetSynd regardless of total adiposity in both cohorts
- P < 0.05
- EFIGRO: associations of IMAAT with HOMA-IR and TG/HDL ratio independent of total adiposity
- P < 0.05
- IMAAT–mean arterial pressure (MAP) relationship attenuated after controlling for total adiposity in both cohorts
- P < 0.09
- AMT/total abdominal area (TAA) ratio inversely associated with TG/HDL ratio, MAP, HOMA-IR and MetSynd in both cohorts
- P < 0.01
- High IMAAT + low AMT/TAA ratio vs low IMAAT + high AMT/TAA ratio: significantly higher HOMA-IR in both cohorts
- P < 0.01
- High IMAAT + low AMT/TAA ratio vs low IMAAT + high AMT/TAA ratio: significantly higher MetSynd in both cohorts
- P < 0.05
Observational data: associations, not effects.
Original publication
Abdominal skeletal muscle quality and quantity are independently and jointly associated with cardiometabolic health in children. Int J Obes (Lond). Published 16 September 2025. doi:10.
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