Development of genome‐wide association studies on childhood obesity and its indicators: A scoping review and enrichment analysis
Authors' conclusion
The innovations in tools and methods enable GWAS to better explore the genetic characteristics of obesity in children and adolescents. However, the number of GWAS in American, Asian and African populations is limited compared to the European population.
Study context
- Population
- Genome-wide association studies (GWAS) of childhood BMI, body fatness and obesity; PubMed, Web of Science, Embase and GWAS Catalog searched 1 January 2005 to 19 October 202220 articles
- Outcome
- GWAS loci for childhood obesity and its indicators
Main finding
As reported in the abstract
- Articles included (published 2007–2021)
- 20
- SNPs reaching genome-wide significance
- 116
- SNPs associated with childhood BMI
- 50
- SNPs associated with body fatness
- 31
- SNPs associated with obesity
- 35
- Studies in European populations
- 16
- Studies in non-European populations (1 East Asian; 1 American; 1 Mexican)
- 3
- Trans-ancestry studies
- 1
Further findings
Enrichment analysis of genes associated with childhood obesity and its indicators
- Several enriched pathways, tissues and diseases identified
Original publication
Development of genome‐wide association studies on childhood obesity and its indicators: A scoping review and enrichment analysis. Pediatr Obes. Published 6 October 2023. doi:10.
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