Metabolomic Changes After Bariatric Surgery Adjusted for Glomerular Filtration Rate Suggest Mechanisms of Kidney Protection
Authors' conclusion
We discovered several GFR-independent metabolomic changes after bariatric surgery which may underlie its beneficial kidney effects including decreased inflammation, oxidation, and insulin resistance. Further studies are needed to investigate the potential mechanistic role of identified metabolites to clarify mechanisms of obesity-related kidney disease.
Study context
- Population
- Adults with severe obesity who underwent bariatric surgery
- Participants
- 27 adults
- Exposure
- Before vs 6 months after bariatric surgery
- Outcome
- Bariatric surgery- and mGFR-associated changes in serum metabolites
- Follow-up
- 1-3 months before and 6 months after surgery
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Serum metabolites significantly associated with bariatric surgery after adjustment
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Pathways downregulated after surgery: alpha-linoleic acid and linoleic acid, methionine, kynurenine, alanine-glucose metabolism
raw p < 0.05
Pathways upregulated after surgery: phenylacetate, bile acid biosynthesis, taurine and hypo-taurine metabolism, porphyrin metabolism
raw p < 0.05
Observational data: associations, not effects.
Original publication
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