Metabolically healthy obesity and left ventricular geometric remodelling in Chinese children
Authors' conclusion
Children with MHO had higher odds of left ventricular geometric remodelling than their metabolically healthy normal weight counterparts. Our findings suggest MHO may not be a benign condition for cardiac health in children.
Study context
- Population
- Chinese children aged 6–11 years; weight status by BMI (WHO growth chart); metabolic status by 2018 consensus criteria (blood pressure, lipids, glucose)
- Participants
- 2,871 children
- Exposure
- Categories of weight and metabolic status vs metabolically healthy normal weight
- Outcome
- Left ventricular geometric remodelling: concentric remodelling, eccentric hypertrophy, concentric hypertrophy
Methodological detailstwo population-based samples
- Two population-based samples
Main finding
As reported in the abstract
Left ventricular geometric remodelling
Estimate (95% CI)
MHOvs MHNW
adjusted OR, concentric remodelling 2.01(1.23–3.28)
MHOvs MHNW
adjusted OR, eccentric hypertrophy 6.36(4.03–10.04)
MHOvs MHNW
adjusted OR, concentric hypertrophy 17.07(7.97–36.58)
MUOvs MHNW
OR, concentric remodelling 2.35(1.47–3.75)
MUOvs MHNW
OR, eccentric hypertrophy 10.85(7.11–16.55)
MUOvs MHNW
OR, concentric hypertrophy 18.56(8.63–39.94)
Observational data: associations, not effects.
Further findings
Sensitivity analyses
- Findings consistent with different definitions of weight, metabolic status and left ventricular geometric remodelling
Original publication
Metabolically healthy obesity and left ventricular geometric remodelling in Chinese children. Diabetes Obes Metab. Published 7 August 2024. doi:10.
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