The cardiovascular exercise response in children with overweight or obesity measured by cardiovascular magnetic resonance imaging
An erratum to this article was published (Int J Obes (Lond), Nov 2024 ↗)
Authors' conclusion
Childhood BMI is, across the full range, associated with a blunted blood pressure response to static exercise but there were no differences in cardiac response to exercise. Our findings suggest that adiposity may especially affect the vascular exercise reaction without affecting cardiac response.
Study context
- Population
- Children from the Generation R population-based prospective cohort, mean age 16 years
- Participants
- 41 vs 166
- Exposure
- Children with overweight or obesity vs normal weight; associations across the full range of BMI
- Overweight or obesityn = 41
- Normal weightn = 166reference
- Outcome
- Cardiovascular exercise response (heart rate, blood pressure and CMR measurements during rest, isometric exercise and recovery)
Methodological detailssubgroup of Generation R, isometric exercise stress test, cardiovascular magnetic resonance (CMR) at rest and exercise
- Subgroup of Generation R
- Isometric exercise stress test
- CMR at rest and exercise
Main finding
As reported in the abstract
Blood pressure response to isometric exercise by BMI
- Higher BMI: higher resting systolic BP, difference (SDS)
- 0.24 SDS (95% CI 0.10, 0.37)
- Higher BMI: higher resting diastolic BP, difference (SDS)
- 0.20 SDS (95% CI 0.06, 0.33)
- Higher BMI: lower systolic BP increase from rest to peak exercise
- −0.11 SDS (95% CI −0.20, −0.03)
- Higher BMI: lower diastolic BP increase from rest to peak exercise
- −0.07 SDS (95% CI −0.07, −0.01)
- BMI associated with slower decrease in systolic and diastolic BP during recovery
- p values < 0.05
Observational data: associations, not effects.
Further findings
Cardiac structure and cardiac response to exercise by BMI
- Higher BMI associated with lower BSA-corrected LV mass, end-diastolic volume and stroke volume
- P < 0.05
- No associations of BMI with cardiac response to exercise (heart rate and CMR measurements)
Original publication
The cardiovascular exercise response in children with overweight or obesity measured by cardiovascular magnetic resonance imaging. Int J Obes (Lond). Published 6 August 2024. doi:10.
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