Associations of the triglyceride-glucose index and its obesity-related derivatives with cardiac structure, function, and incident atrial fibrillation: a prospective cohort study using cardiac magnetic resonance
Authors' conclusion
TyG obesity-related derivatives, particularly TyG-WC, were independently associated with incident AF. Cardiac structural remodeling, especially LA enlargement, appeared to be a key mediating pathway. These findings support the importance of early metabolic intervention to prevent adverse atrial remodeling and reduce AF susceptibility.
Study context
- Population
- UK Biobank participants free of atrial fibrillation (AF) who underwent baseline cardiac magnetic resonance (CMR) imaging1,288 incident AF cases
- Participants
- 32,500 participants
- Comparison
- Triglyceride-glucose (TyG) index and its obesity-related derivatives and incident AF
- Primary endpoint
- Incident AF
- Follow-up
- Median 13.61 years
Methodological detailsUK Biobank, cardiac magnetic resonance, multivariable Cox regression, mediation analysis
- UK Biobank
- Cardiac magnetic resonance
- Multivariable Cox regression
- Mediation analysis
Primary result
As reported in the abstract
TyG-WC, HR
1.245
95% CI 1.169–1.325
TyG-BMI, HR
1.223
95% CI 1.158–1.293
TyG-WHtR, HR
1.190
95% CI 1.122–1.262
Further findings
Proportion of association mediated by left atrial maximum volume (LAVmax), the predominant mediator
- TyG-BMI
- 70.63%
- TyG-WHtR
- 47.83%
- TyG-WC
- 40.79%
Original publication
Associations of the triglyceride-glucose index and its obesity-related derivatives with cardiac structure, function, and incident atrial fibrillation: a prospective cohort study using cardiac magnetic resonance. Cardiovasc Diabetol. Published 31 March 2026. doi:10.
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