Comparing the metabolic signatures of obesity defined by waist circumference, waist‐hip ratio, or BMI
Authors' conclusion
This study identified unique metabolic signatures associated with obesity based on different measurements in the Qatari population. These findings contribute to a better understanding of the molecular pathways involved in obesity and may have implications for developing personalized prevention and treatment strategies.
Study context
- Population
- Qatari population; serum samples
- Exposure
- Obesity defined by waist circumference vs WHR vs BMI
- Outcome
- Metabolic signatures associated with each measure of obesity
Methodological detailsmetabolomics profiling, Inverse rank normalization, principal component analysis and orthogonal partial least square-discriminant analysis
- Metabolomics profiling
- Inverse rank normalization, principal component analysis and orthogonal partial least square-discriminant analysis
Main finding
As reported in the abstract
Metabolic signatures by obesity measure
- Significant differences in metabolites associated with obesity based on different measurements
- Men: phosphatidylcholine and phosphatidylethanolamine metabolites significantly enriched in obesity by WHR
- Women: significant changes in leucine, isoleucine and valine metabolism metabolites
- Unique metabolites in the different categorization groups, potential biomarkers for obesity-related disorders
Observational data: associations, not effects.
Original publication
Comparing the metabolic signatures of obesity defined by waist circumference, waist‐hip ratio, or BMI. Obesity (Silver Spring). Published 5 July 2024. doi:10.
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