Association between weight loss and cardiovascular outcomes and mortality in Korea: A nationwide cohort study
Authors' conclusion
Weight loss of more than 3% is associated with an increased risk of a combined CVD events, consistent across most risk factors. However, regular exercise may reduce the adverse effects on CVD mortality, suggesting a potential protective role of physical activity.
Study context
- Population
- Adults aged 40–80 years with at least two general health checkups within a 2-year interval in Korea
- Participants
- 1,020,533 adults
- Exposure
- Weight loss vs no weight loss
- Outcome
- Incidence of CVD outcomes (combined CVD events)
- Follow-up
- 7.2 years
Methodological detailsnationwide, Weight measured by trained examiners at certified hospitals, Cox proportional hazards models
- Nationwide
- Weight measured by trained examiners at certified hospitals
- Cox proportional hazards models
Main finding
As reported in the abstract
Combined CVD events
Hazard ratio (95 % CI)
Moderate weight loss
1.24(1.21–1.28)
Severe weight loss
1.45(1.33–1.57)
Observational data: associations, not effects.
Further findings
- Weight loss significantly associated with increased risk of both nonfatal cardiovascular disease (CVD) events and CVD mortality; regular exercise mitigated the adverse effects on CVD mortality
Original publication
Association between weight loss and cardiovascular outcomes and mortality in Korea: A nationwide cohort study. Diabetes Res Clin Pract. Published 4 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →