Associations of metabolic changes and polygenic risk scores with cardiovascular outcomes and all-cause mortality across body mass index (BMI) categories: a prospective cohort study
Authors' conclusion
MH status and a low PRS are associated with a lower risk of adverse cardiovascular outcomes and all-cause mortality across all BMI categories. This protective effect is particularly pronounced in individuals younger than 65 years. Further research is required to confirm these findings in diverse populations and to investigate the underlying mechanisms involved.
Study context
- Population
- UK Biobank participants (mean age 56.55; male 45.9%)
- Participants
- 481,576 participants
- Exposure
- Metabolic status, metabolic transitions and polygenic risk score (PRS) across BMI categories vs metabolically unhealthy obesity
- Outcome
- All-cause mortality, CVD mortality and CVD morbidity
- Follow-up
- Median 14.38 years
Methodological detailsUK Biobank, Cox regression
- UK Biobank
- Cox regression
Main finding
As reported in the abstract
Hazard ratio (95% CI)
MH overweightvs Metabolically unhealthy obesityAll-cause mortality, high PRS; lowest risk
0.70(0.65–0.76)
MH overweightvs Metabolically unhealthy obesityCVD mortality, high PRS; lowest risk
0.57(0.50–0.64)
MH normal weightvs Metabolically unhealthy obesityCVD morbidity; lowest risk
0.54(0.51–0.57)
- All-cause deaths
- 31,883 (7.3%)
- Cardiovascular disease (CVD) deaths
- 8133 (1.8%)
- CVD cases
- 67,260 (14.8%)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Age subgroup: inverse associations of metabolic status and PRS more pronounced in age <65 yearsAge <65 years vs Age ≥65 years | P for interaction < 0.05 |
Metabolic transitions and PRS
- Combined protective effects of metabolic transitions and PRS on outcomes among BMI categories observed
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Associations of metabolic changes and polygenic risk scores with cardiovascular outcomes and all-cause mortality across BMI categories: a prospective cohort study. Cardiovasc Diabetol. Published 4 July 2024. doi:10.
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