Plasma metabolomic profile of adiposity and body composition in childhood: The Genetics of Glucose regulation in Gestation and Growth cohort
Authors' conclusion
A module of metabolites was associated with adiposity measures in childhood.
Study context
- Population
- Children at mid-childhood (age 5.3 ± 0.3 years; BMI 15.7 ± 1.5 kg/m²) from the Gestation and Growth (Gen3G) prospective pre-birth cohort
- Participants
- 329 children
- Outcome
- Association of 'green' metabolite module (120 metabolites, mostly sphingomyelins and phosphatidylcholine) with adiposity
- Follow-up
- Mid-childhood
Methodological detailswithin prospective pre-birth cohort (Gen3G), weighted-correlation network analysis, Spearman's partial correlations with false discovery rate (FDR) correction, 1038 plasma metabolites quantified; body composition by DXA, skinfold, waist circumference and BMI
- Within prospective pre-birth cohort (Gen3G)
- Weighted-correlation network analysis
- Spearman's partial correlations with FDR correction
- 1038 plasma metabolites quantified; body composition by DXA, skinfold, waist circumference and BMI
Main finding
As reported in the abstract
Correlation with DXA total and truncal fat (ρadjusted)
0.11-0.19
Correlation with skinfold measures (ρadjusted)
0.09-0.26
Correlation with BMI (ρadjusted)
0.15
Correlation with waist circumference (ρadjusted)
0.18
Observational data: associations, not effects.
Further findings
Module correlations stratified by sex
- Correlations similar when stratified by sex
Individual metabolites within module
- Sphingomyelin (d18:2/14:0, d18:1/14:1)* showed the strongest associations
Original publication
Plasma metabolomic profile of adiposity and body composition in childhood: The Genetics of Glucose regulation in Gestation and Growth cohort. Pediatr Obes. Published 3 July 2024. doi:10.
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